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Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal–organic frameworks
journal contribution
posted on 2023-06-08, 16:11 authored by Andrew D Burrows, Monika Jurcic, Luke L Keenan, Rebecca A Lane, Mary F Mahon, Mark R Warren, Harriot Nowell, Michael Paradowski, John SpencerJohn SpencerA series of new zinc-based metal–organic framework materials has been prepared in which deferiprone is incorporated as a chelating ligand on infinite or tri-zinc secondary building units following deprotonation. Deferiprone is immediately released from the MOFs on treatments with 1 N hydrochloric acid or buffer, but slow release is observed in ethanoic acid.
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Publication status
- Published
File Version
- Published version
Journal
Chemical CommunicationsISSN
1359-7345Publisher
Royal Society of ChemistryExternal DOI
Volume
49Page range
11260-11262Department affiliated with
- Chemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2013-10-23First Open Access (FOA) Date
2014-10-17First Compliant Deposit (FCD) Date
2014-07-18Usage metrics
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