Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal–organic frameworks

Burrows, Andrew D, Jurcic, Monika, Keenan, Luke L, Lane, Rebecca A, Mahon, Mary F, Warren, Mark R, Nowell, Harriot, Paradowski, Michael and Spencer, John (2013) Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal–organic frameworks. Chemical Communications, 49. pp. 11260-11262. ISSN 1359-7345

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Abstract

A series of new zinc-based metal–organic framework materials has been prepared in which deferiprone is incorporated as a chelating ligand on infinite or tri-zinc secondary building units following deprotonation. Deferiprone is immediately released from the MOFs on treatments with 1 N hydrochloric acid or buffer, but slow release is observed in ethanoic acid.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science
Depositing User: Deeptima Massey
Date Deposited: 23 Oct 2013 09:55
Last Modified: 15 Mar 2017 02:45
URI: http://sro.sussex.ac.uk/id/eprint/46792

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