The contribution of host genetics to TB disease

Newport, Melanie J (2013) The contribution of host genetics to TB disease. Current Respiratory Medicine Reviews, 9 (3). pp. 156-162. ISSN 1573-398X

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Abstract

There is robust epidemiological evidence that susceptibility to tuberculosis is in part heritable. This has driven the use of genetics to try to find the genes and pathways involved that could in the longer term contribute towards the development of new therapies and a better vaccine for this major global health problem. This paper reviews the progress made in the field to date, and discusses the challenges inherent in undertaking genetics studies on a complex disease with clinically diverse phenotypes, that affects many genetically different populations and which is further complicated by the presence of a pathogen which has a genome too.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Global Health and Infection
Subjects: R Medicine > RC Internal medicine > RC0109 Infectious and parasitic diseases
Depositing User: Melanie Newport
Date Deposited: 18 Oct 2013 14:22
Last Modified: 03 Aug 2017 17:03
URI: http://sro.sussex.ac.uk/id/eprint/46745

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