One ring to rule them all? Another cellular responsibility for PCNA

Green, C. M. (2006) One ring to rule them all? Another cellular responsibility for PCNA. Trends in Molecular Medicine, 12 (10). pp. 455-458. ISSN 1471-4914

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Abstract

To prevent duplication or loss of genomic regions during DNA replication, it is essential that the entire genome is copied precisely once every S phase. Cells achieve this by mutually exclusive regulation of origin firing and licensing. A crucial protein that is involved in origin licensing is chromatin licensing and DNA replication factor 1 (CDT1) and, therefore, activity of this protein must be strictly controlled. Four recent articles have demonstrated that proliferating cell nuclear antigen (PCNA), an essential sliding clamp used in replication and DNA repair, has a crucial role in this process by mediating the proteasomal degradation of CDT1.

Item Type: Article
Additional Information: Published by Elsevier
Subjects: R Medicine > R Medicine (General)
Q Science > QD Chemistry
Q Science > QH Natural history > QH0301 Biology
Depositing User: Catherine Mary Green
Date Deposited: 14 Nov 2006
Last Modified: 10 Mar 2017 22:20
URI: http://sro.sussex.ac.uk/id/eprint/461
Google Scholar:3 Citations

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