Declining prevalence of HIV-1 drug resistance in antiretroviral treatment-exposed individuals in Western Europe

De Luca, Andrea, Fisher, Martin and The SHERE Collaboration, (2013) Declining prevalence of HIV-1 drug resistance in antiretroviral treatment-exposed individuals in Western Europe. The Journal of infectious diseases, 207 (8). pp. 1216-1220. ISSN 1537-6613

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Abstract

HIV-1 drug resistance represents a major obstacle to infection and disease control. This retrospective study analyzes trends and determinants of resistance in antiretroviral treatment (ART)-exposed individuals across 7 countries in Europe. Of 20 323 cases, 80% carried at least one resistance mutation: these declined from 81% in 1997 to 71% in 2008. Predicted extensive 3-class resistance was rare (3.2% considering the cumulative genotype) and peaked at 4.5% in 2005, decreasing thereafter. The proportion of cases exhausting available drug options dropped from 32% in 2000 to 1% in 2008. Reduced risk of resistance over calendar years was confirmed by multivariable analysis.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Subjects: R Medicine > RC Internal medicine > RC0109 Infectious and parasitic diseases
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Depositing User: Ellen Thomas
Date Deposited: 19 Aug 2013 09:12
Last Modified: 19 Aug 2013 09:12
URI: http://sro.sussex.ac.uk/id/eprint/45872
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