British HIV Association guidelines for the treatment of HIV-1-infected adults with antiretroviral therapy 2008

Gazzard, B G, Anderson, Jane, Babiker, Abdel, Boffito, Marta, Brook, Gary, Brough, Gary, Churchill, Duncan, Cromarty, Ben, Das, Satyajit, Fisher, Martin, Freedman, Andrew, Geretti, Anna Maria, Johnson, Margaret, Khoo, Saye, Leen, Clifford, Nair, Devaki, Peters, Barry, Phillips, Andrew, Pillay, Deenan, Pozniak, Anton, Walsh, John, Wilkins, Ed, Williams, Ian, Williams, Matthew and Youle, Mike (2008) British HIV Association guidelines for the treatment of HIV-1-infected adults with antiretroviral therapy 2008. HIV medicine, 9 (8). pp. 563-608. ISSN 1468-1293

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Abstract

The 2008 BHIVA Guidelines have been updated to incorporate all the new relevant information (including presentations at the 15th Conference on Retroviruses and Opportunistic Infections 2008) since the last iteration. The guidelines follow the methodology outlined below and all the peer-reviewed publications and important, potentially treatment-changing abstracts from the last 2 years have been reviewed.

The translation of data into clinical practice is often difficult even with the best possible evidence (i.e. two randomized controlled trials) because of trial design, inclusion criteria and precise surrogate marker endpoints (see Appendix). The recommendations based upon expert opinion have the least good evidence but perhaps provide an important reason for writing the guidelines to produce a consensual opinion about current practice. It must, however, be appreciated that such opinion is often wrong and should not stifle research to challenge it.

Similarly, although the Writing Group seeks to provide guidelines to optimize treatment, such care needs to be individualized and we have not constructed a document that we would wish to see used as a ‘standard’ for litigation.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Subjects: R Medicine > RC Internal medicine > RC0109 Infectious and parasitic diseases
Depositing User: Ellen Thomas
Date Deposited: 05 Aug 2013 13:04
Last Modified: 05 Aug 2013 13:04
URI: http://sro.sussex.ac.uk/id/eprint/45618
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