Modelling and simulation of cell migration in heterogeneous media

Elliott, Charles Martin, Stinner, Bjorn, Styles, Vanessa, Venkataraman, Chandrasekhar and Unset (2015) Modelling and simulation of cell migration in heterogeneous media. In: Nithiarasu, Perumal and Budyn, Elisa (eds.) CMBE15: 4th International Conference on Computational & Mathematical Biomedical Engineering, 29th June - 1st July 2015 École Normale Supéerieure de Cachan, Cachan (Paris) France. CMBE, pp. 401-404. ISBN 9780956291431

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Abstract

Cell motility is a complex process comprising, among others, cytoskeletal remodelling and growth,
active force generation, chemical transport and reaction of multiple substances inside and outside the
cell as well as on the cell membrane, anisotropic material behavior of the cell and of the extracellular
matrix (ECM), and proteolytic cleavage of the ECM. We are working on an evolving finite element
based computational framework that is able to incorporate models and methods for all the key features
of cell motility. The approach exploits a mesoscopic point of view and aims at a comprehensive 3D
model allowing for the simulation of cell motility at reasonable computational costs. In the presentation
we will first sketch the overall framework, addressing all the respective models and methods,
and will then focus on some essential subunits.

Item Type: Book Section
Schools and Departments: School of Mathematical and Physical Sciences > Mathematics
Subjects: Q Science > QR Microbiology
Depositing User: Chandrasekhar Venkataraman
Date Deposited: 24 Nov 2015 13:16
Last Modified: 24 Nov 2015 13:16
URI: http://sro.sussex.ac.uk/id/eprint/45599

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