Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary diseasa

Huang, Jeffrey T-J, Chaudhuri, Rekha, Albarbarawi, Osama, Barton, Alun, Grierson, Christal, Rauchhaus, Petra, Weir, Christopher J, Messow, Martina, Stevens, Nicola, McSharry, Charles, Feuerstein, Giora, Mukhopadhyay, Somnath, Brady, Jeffrey, Palmer, Colin N A, Miller, Douglas and Thomson, Neil C (2012) Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary diseasa. Thorax, 67 (6). pp. 502-508. ISSN 1468-3296

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Abstract

Background Although an increased concentration of
degraded elastin products in patients with chronic
obstructive pulmonary disease (COPD) has been reported
for many years, its clinical validity and utility remain
uncertain due to technical difficulties, small study groups
and the unknown relationship between exacerbation and
elastin degradation. The objectives of this study were to
determine the validity of urinary and blood total
desmosine/isodesmosine in patients with COPD and
asthma and to evaluate their relationship to exacerbation
status and lung function.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Subjects: R Medicine > RJ Pediatrics > RJ0101 Child health. Child health services
Depositing User: Judy Keogh
Date Deposited: 21 May 2013 09:58
Last Modified: 13 Mar 2017 11:10
URI: http://sro.sussex.ac.uk/id/eprint/44792

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