FMRI resting slow fluctuations correlate with the activity of fast cortico-cortical physiological connections

Koch, Giacomo, Bozzali, Marco, Bonnì, Sonia, Giacobbe, Viola, Caltagirone, Carlo and Cercignani, Mara (2012) FMRI resting slow fluctuations correlate with the activity of fast cortico-cortical physiological connections. PLoS ONE, 7 (12). e52660. ISSN 1932-6203

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Abstract

Recording of slow spontaneous fluctuations at rest using functional magnetic resonance imaging (fMRI) allows distinct long-range cortical networks to be identified. The neuronal basis of connectivity as assessed by resting-state fMRI still needs to be fully clarified, considering that these signals are an indirect measure of neuronal activity, reflecting slow local variations in de-oxyhaemoglobin concentration. Here, we combined fMRI with multifocal transcranial magnetic stimulation (TMS), a technique that allows the investigation of the causal neurophysiological interactions occurring in specific cortico-cortical connections. We investigated whether the physiological properties of parieto-frontal circuits mapped with short-latency multifocal TMS at rest may have some relationship with the resting-state fMRI measures of specific resting-state functional networks (RSNs). Results showed that the activity of fast cortico-cortical physiological interactions occurring in the millisecond range correlated selectively with the coupling of fMRI slow oscillations within the same cortical areas that form part of the dorsal attention network, i.e., the attention system believed to be involved in reorientation of attention. We conclude that resting-state fMRI ongoing slow fluctuations likely reflect the interaction of underlying physiological cortico-cortical connections.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Laboratory Investigation
Subjects: Q Science > QP Physiology > QP0351 Neurophysiology and neuropsychology
R Medicine
Depositing User: Patricia Butler
Date Deposited: 13 May 2013 13:49
Last Modified: 01 Apr 2017 08:53
URI: http://sro.sussex.ac.uk/id/eprint/44671

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