Dynamic coding for cognitive control in prefrontal cortex

Stokes, Mark G, Kusunoki, Makoto, Sigala, Natasha, Nili, Hamed, Gaffan, David and Duncan, John (2013) Dynamic coding for cognitive control in prefrontal cortex. Neuron, 78 (2). pp. 364-375. ISSN 0896-6273

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Abstract

Cognitive flexibility is fundamental to adaptive intelligent behavior. Prefrontal cortex has long been associated with flexible cognitive function, but the neurophysiological principles that enable prefrontal cells to adapt their response properties according to context-dependent rules remain poorly understood. Here, we use time-resolved population-level neural pattern analyses to explore how context is encoded and maintained in primate prefrontal cortex and used in flexible decision making. We show that an instruction cue triggers a rapid series of state transitions before settling into a stable low-activity state. The postcue state is differentially tuned according to the current task-relevant rule. During decision making, the response to a choice stimulus is characterized by an initial stimulus-specific population response but evolves to different final decision-related states depending on the current rule. These results demonstrate how neural tuning profiles in prefrontal cortex adapt to accommodate changes in behavioral context. Highly flexible tuning could be mediated via short-term synaptic plasticity.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
Depositing User: Natasha Sigala
Date Deposited: 17 Apr 2013 13:47
Last Modified: 27 Jul 2017 18:27
URI: http://sro.sussex.ac.uk/id/eprint/44328
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