Gold amides as anticancer drugs: synthesis and activity studies

Newcombe, Sonya, Bobin, Mariusz, Shrikhande, Amruta, Gallop, Chris, Pace, Yannick, Yong, Helen, Gates, Rebecca, Chaudhuri, Shuvashri, Roe, Mark, Hoffmann, Eva and Viseux, Eddy M E (2013) Gold amides as anticancer drugs: synthesis and activity studies. Organic and Biomolecular Chemistry, 19 (11). pp. 3255-3260. ISSN 1477-0520

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Abstract

Modular gold amide chemotherapeutics: Access to modern chemotherapeutics with robust and flexible synthetic routes that are amenable to extensive customisation is a key requirement in drug synthesis and discovery. A class of chiral gold amide complexes featuring amino acid derived ligands is reported herein. They all exhibit in vitro cytotoxicity against two slow growing breast cancer cell lines with limited toxicity towards normal epithelial cells.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science
Q Science > QD Chemistry
Q Science > QD Chemistry > QD0146 Inorganic chemistry
Q Science > QD Chemistry > QD0241 Organic chemistry
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology Including cancer and carcinogens
R Medicine > RD Surgery > RD0651 Neoplasms. Tumors. Oncology
R Medicine > RM Therapeutics. Pharmacology > RM0300 Drugs and their actions
R Medicine > RM Therapeutics. Pharmacology > RM0671 Nonprescription drugs. Patent medicines
R Medicine > RS Pharmacy and materia medica > RS0153 Materia medica > RS0400 Pharmaceutical chemistry
Depositing User: Eddy Viseux
Date Deposited: 15 Apr 2013 12:34
Last Modified: 08 Mar 2017 01:58
URI: http://sro.sussex.ac.uk/id/eprint/44189

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