The structure of cross-β tapes and tubes formed by an octapeptide, αSβ1

Morris, Kyle L, Zibaee, Shahin, Chen, Lin, Goedert, Michel, Sikorski, Pawel and Serpell, Louise C (2013) The structure of cross-β tapes and tubes formed by an octapeptide, αSβ1. Angewandte Chemie International Edition, 52 (8). pp. 2279-2283. ISSN 1433-7851

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Abstract

Elaborate morphology: The αSβ1 peptide, a fragment of α-synuclein, assembles into flat tapes consisting of a peptide bilayer, which can be modeled based on the cross-β structure found in amyloid proteins. The tapes are stabilized by hydrogen bonding, whilst the amphiphilic nature of the peptide results in the thin bilayer structure. To further stabilize the structure, these tapes may twist to form helical tapes, which subsequently close into nanotubes.

Item Type: Article
Keywords: helical structure;nanotubes;peptides;self-assembly;X-ray diffraction
Schools and Departments: School of Life Sciences > Biochemistry
Subjects: Q Science
Depositing User: Louise Serpell
Date Deposited: 14 Feb 2013 11:47
Last Modified: 08 Mar 2017 04:48
URI: http://sro.sussex.ac.uk/id/eprint/43525

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