Phage display in the study of infectious diseases

Mullen, Lisa M, Nair, Sean P, Ward, John M, Rycroft, Andrew N and Henderson, Brian (2006) Phage display in the study of infectious diseases. Trends in Microbiology, 14 (3). pp. 141-147. ISSN 0966-842X

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Abstract

Microbial infections are dependent on the panoply of interactions between pathogen and host and identifying the molecular basis of such interactions is necessary to understand and control infection. Phage display is a simple functional genomic methodology for screening and identifying protein-ligand interactions and is widely used in epitope mapping, antibody engineering and screening for receptor agonists or antagonists. Phage display is also used widely in various forms, including the use of fragment libraries of whole microbial genomes, to identify peptide-ligand and protein-ligand interactions that are of importance in infection. In particular, this technique has proved successful in identifying microbial adhesins that are vital for colonization.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Laboratory Investigation
Subjects: Q Science > QR Microbiology > QR0001 General
Depositing User: Lisa Mullen
Date Deposited: 18 Jan 2013 11:56
Last Modified: 18 Jan 2013 11:56
URI: http://sro.sussex.ac.uk/id/eprint/43411
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