Common variable immunodeficiency: an update on etiology and management

Yong, Patrick F K, Tarzi, Michael, Chua, Ignatius, Grimbacher, Bodo and Chee, Ronnie (2008) Common variable immunodeficiency: an update on etiology and management. Immunology and Allergy Clinics of North America, 28 (2). pp. 367-386. ISSN 0889-8561

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Abstract

Common variable immunodeficiency (CVID) represents a heterogeneous group of primary antibody deficiency disorders characterized by recurrent infection and by inflammatory, granulomatous, and autoimmune complications. Recently, there have been significant advances in understanding the pathogenesis of the disease, with five genetic mutations identified in patients who have a CVID phenotype. Clinical care also has progressed with refinements in treatment and the development of classification schemes for prognostic and research purposes. Significant delays in diagnosis remain, however. It is likely that more genetic defects will be identified in the future, further shrinking the pool of patients who have CVID of unknown cause

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Brighton and Sussex Medical School > Division of Medical Education
Subjects: R Medicine
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Depositing User: Patricia Butler
Date Deposited: 30 Nov 2012 08:01
Last Modified: 22 Sep 2017 13:08
URI: http://sro.sussex.ac.uk/id/eprint/43149
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