Brain structure and joint hypermobility: relevance to the expression of psychiatric symptoms

Eccles, Jessica A, Beacher, Felix D C, Gray, Marcus A, Jones, Catherine L, Minati, Ludovico, Harrison, Neil A and Critchley, Hugo D (2012) Brain structure and joint hypermobility: relevance to the expression of psychiatric symptoms. The British Journal of Psychiatry, 200 (6). pp. 508-509. ISSN 0007-1250

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Abstract

Joint hypermobility is overrepresented among people with anxiety and can be associated with abnormal autonomic reactivity. We tested for associations between regional cerebral grey matter and hypermobility in 72 healthy volunteers using voxel-based morphometry of structural brain scans. Strikingly, bilateral amygdala volume distinguished those with from those without hypermobility. The hypermobility group scored higher for interoceptive sensitivity yet were not significantly more anxious. Our findings specifically link hypermobility to the structural integrity of a brain centre implicated in normal and abnormal emotions and physiological responses. Our observations endorse hypermobility as a multisystem phenotype and suggest potential mechanisms mediating clinical vulnerability to neuropsychiatric symptoms

Item Type: Article
Keywords: PANIC DISORDER; ANXIETY
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > R Medicine (General) > R895 Medical physics. Medical radiology. Nuclear medicine
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
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Depositing User: Hazelle Woodhurst
Date Deposited: 28 Nov 2012 10:19
Last Modified: 26 Sep 2017 10:53
URI: http://sro.sussex.ac.uk/id/eprint/43074
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