Determination of prooxidant--antioxidant balance after acute coronary syndrome using a rapid assay: a pilot study

Ghayour-Mobarhan, Majid, Alamdari, Daryoush Hamidi, Moohebati, Mohsen, Sahebkar, Amirhossein, Nematy, Mohsen, Safarian, Mohammad, Azimi-Nezhad, Mohsen, Parizadeh, Seyyed Mohammad Reza, Tavallaie, Shima, Koliakos, George and Ferns, Gordon (2009) Determination of prooxidant--antioxidant balance after acute coronary syndrome using a rapid assay: a pilot study. Angiology, 60 (6). pp. 657-662. ISSN 1940-1574

Full text not available from this repository.

Abstract

The purpose of the current study was to investigate a novel measure of oxidative stress in patients with acute coronary syndrome (ACS) using a pro-oxidant-antioxidant balance (PAB) assay, which is simple and rapid. Blood samples were taken from 94 patients admitted with ACS. Pro-oxidant-antioxidant balance values were determined in the first and second 12 hours after the onset of symptoms and compared with values for 81 age- and sex-matched controls. The mean PAB values in the first and second 12-hour samples of patients were both significantly higher than that of controls (P < .001). Among patients, PAB values were also significantly higher in the second samples compared with the first samples (P < .001). These findings indicate a heightened state of oxidative stress following ACS and suggest that the PAB value may be considered as a cardiovascular risk predictor to estimate the extent of oxidative stress

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Subjects: R Medicine > R Medicine (General) > R735 Medical education
Depositing User: Gordon Ferns
Date Deposited: 19 Nov 2012 14:45
Last Modified: 19 Nov 2012 14:45
URI: http://sro.sussex.ac.uk/id/eprint/42702
📧 Request an update