Changes in pro-oxidant-antioxidant balance after bare metal and drug eluting stent implantation in patients with stable coronary disease

Falsoleiman, Homa, Dehghani, Mashalla, Moohebati, Mohsen, Fazlinezhad, Afsoon, Daloee, Mahdi Hassanzadeh, Alamdari, Daryoush Hamidi, Esmaily, Habib Ollah, Parizadeh, Seyyed Mohammad Reza, Tavallaie, Shima, Rahsepar, Amir Ali, Paydar, Roghayeh, Kazemi-Bajestani, Seyyed Mohammad Reza, Pourghadam-Yari, Hossein, Parizad, Parisa Abbasi, Ghayour-Mobarhan, Majid and Ferns, Gordon A (2011) Changes in pro-oxidant-antioxidant balance after bare metal and drug eluting stent implantation in patients with stable coronary disease. Clinical Biochemistry, 44 (2-3). pp. 160-164. ISSN 0009-9120

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Abstract

OBJECTIVES

In this study we aimed to assess the changes in pro-oxidant-antioxidant balance (PAB) after the placement of either a drug-eluting-stent (DES) or bare-metal-stent (BMS) in patients with stable coronary artery disease.

DESIGN AND METHODS

Percutaneous coronary interventions (PCI) with either BMS or DES were undertaken for 152 patients (82 in the BMS and 70 in the DES groups respectively). PAB values were measured 24h before and after PCI.

RESULTS

Baseline PAB values were 80.68 (64.98-99.37) and 98.86 (64.70-140.62) for BMS and DES group, respectively, which were not significantly different between the 2 groups (P>0.05). Following PCI, median PAB values decreased to 72.10 (61.40-96.13) and 81.40 (54.15-121.90) in BMS and DES groups, respectively. The reduction was significant in both BMS and DES groups (P<0.05). The changes in PAB values were -2.81 (-12.76 to 2.31) for BMS and -2.82 (-29.88 to 8.93) for DES group, which were not significantly different between the 2 groups (P>0.05).

CONCLUSION

We found that the reported difference in clinical outcomes following DES or BMS implantation cannot be attributed to differences in early changes in oxidative stress induction as assessed by changes in PAB values

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Subjects: R Medicine > R Medicine (General) > R735 Medical education
Depositing User: Gordon Ferns
Date Deposited: 19 Nov 2012 07:14
Last Modified: 19 Nov 2012 07:14
URI: http://sro.sussex.ac.uk/id/eprint/42653
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