Prooxidant-anti-oxidant balance is not associated with extent of coronary artery disease

Rahsepar, Amir Ali, Pourghadamyari, Hossein, Moohebati, Mohsen, Parizadeh, Seyyed Mohammad Reza, Tavallaie, Shima, Paydar, Roghayeh, Falsoleiman, Homa, Dehghani, Mashalla, Fazlinezhad, Afsoon, Amini, Maral, Khorashadizadeh, Fatemeh, Ghayour-Mobarhan, Majid and Ferns, Gordon A (2011) Prooxidant-anti-oxidant balance is not associated with extent of coronary artery disease. Clinical biochemistry, 44 (16). pp. 1304-8. ISSN 1873-2933

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Abstract

OBJECTIVE

We have measured the pro-oxidant-antioxidant-balance (PAB) levels in patients with defined coronary artery disease (CAD) and compared them with concentrations in healthy subjects.

DESIGN AND METHODS

Based on angiography results, 400 patients with stable CAD were divided into CAD- and CAD+, this being further subcategorized into groups with single-, double- and triple-vessel disease (VD).

RESULTS

The mean PAB values in the healthy subjects, was significantly lower than for other groups (P<0.001). In CAD- patients, PAB levels were 123.2 ± 43.9, which was not statistically different compared to groups with SVD, 2VD and 3VD (P>0.05). In the CAD+ group, PAB values in 1VD, 2VD and 3VD were not significantly different among patients with SVD, 2VD and 3VD (P>0.05).

CONCLUSIONS

In conclusion, we found higher levels of oxidative stress in CAD+ patients compared to healthy subjects. The oxidation level was not related to measures of the extent of CAD such as number of stenosed vessels.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Subjects: R Medicine > R Medicine (General) > R735 Medical education
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Depositing User: Gordon Ferns
Date Deposited: 19 Nov 2012 09:37
Last Modified: 19 Nov 2012 09:37
URI: http://sro.sussex.ac.uk/id/eprint/42644
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