A cross-sectional study of the association between heat shock protein 27 antibody titers, pro-oxidant-antioxidant balance and metabolic syndrome in patients with angiographically-defined coronary artery disease

Sahebkar, Amirhossein, Pourghadamyari, Hossein, Moohebati, Mohsen, Parizadeh, Seyed Mohammad Reza, Falsoleiman, Homa, Dehghani, Mashallah, Fazlinezhad, Afsoon, Akhlaghi, Saeed, Tavallaie, Shima, Paydar, Roghayeh, Ghayour-Mobarhan, Majid and Ferns, Gordon A (2011) A cross-sectional study of the association between heat shock protein 27 antibody titers, pro-oxidant-antioxidant balance and metabolic syndrome in patients with angiographically-defined coronary artery disease. Clinical biochemistry, 44 (17-18). pp. 1390-1395. ISSN 1873-2933

Abstract

OBJECTIVE

To investigate the association between serum antibody titers to Hsp27 (anti-Hsp27) and pro-oxidant-antioxidant balance (PAB) in patients with angiographically-defined coronary artery disease (CAD) with or without the metabolic syndrome (MS).

DESIGN

Subjects (n=243) were classified into MS+ (n=161) and MS- (n=82) subgroups, based on the AHA/NHBLI criteria.

RESULTS

Serum anti-Hsp27 titers were found to be significantly higher in the MS+ vs. MS- group. However, no significant difference was observed in serum PAB values. When assessed for individual components of MS, increased serum anti-Hsp27 was found to be higher in subgroups with elevated triglycerides, elevated blood pressure and reduced high-density lipoprotein cholesterol (HDL-C). Subgroups of patients with elevated triglycerides had higher PAB values. HDL-C was the only significant predictor of anti-Hsp27 in the population as a whole.

CONCLUSION

The evidence from this investigation indicates the presence of elevated anti-Hsp27 in patients with concurrent CAD and MS compared to those with CAD alone.

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