Changes in small dense low-density lipoprotein levels following acute coronary syndrome

Emadzadeh, Mahdi Reza, Alavi, Maryam-Sadat, Soukhtanloo, Mohammad, Mohammadpour, Toktam, Rahsepar, Amir Ali, Tavallaie, Shima, Khojasteh, Roshanak, Paydar, Roghayeh, Amini, Maral, Parizadeh, Seyyed Mohammad Reza, Akhlaghi, Saeed, Ghayour-Mobarhan, Majid and Ferns, Gordon A (2012) Changes in small dense low-density lipoprotein levels following acute coronary syndrome. Angiology. ISSN 1940-1574

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Abstract

Low-density lipoprotein (LDL), especially small dense LDL (sdLDL), plays a role in atherogenesis. We compared baseline sdLDL levels between healthy controls and patients with acute coronary syndrome (ACS). Blood samples were taken from patients diagnosed with myocardial infarction ([MI] n = 104) and unstable angina ([UA] n = 100). Both sdLDL and high-sensitivity C-reactive protein (hsCRP) levels were determined on admission and in the next 24 hours after the onset of symptoms. Baseline concentration of sdLDL was significantly higher in patients presenting with ACS than controls (P < .05). In the 24 hours following ACS, the sdLDL levels decreased insignificantly in both groups of patients with ACS (P > .05). The changes in sdLDL values were not significantly different between MI and UA participants (P > .05). Patients with ACS have higher concentration of sdLDL compared with the controls.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Subjects: R Medicine > R Medicine (General) > R735 Medical education
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Depositing User: Gordon Ferns
Date Deposited: 16 Nov 2012 15:53
Last Modified: 16 Nov 2012 15:53
URI: http://sro.sussex.ac.uk/id/eprint/42635
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