Prooxidant-antioxidant balance and antioxidized LDL antibody level values and cardiac function in patients with coronary artery disease.

Rahsepar, A A, Mirzaee, A, Moodi, F, Moohebati, M, Tavallaie, S, Eshraghi, A, Alavi, M-S, Khorashadizadeh, F, Pourghadamyari, H, Paydar, R, Amini, M, Khojasteh, R, Mousavi, S, Sahebi, M, Ghayour-Mobarhan, M and Ferns, G A A (2012) Prooxidant-antioxidant balance and antioxidized LDL antibody level values and cardiac function in patients with coronary artery disease. Cardiology, 122 (4). pp. 203-9. ISSN 1421-9751

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Abstract

OBJECTIVES

We studied the association between the prooxidant-antioxidant balance (PAB), anti-malondialdehyde-modified low-density lipoprotein (oxidized LDL, ox-LDL) IgG antibody and indices of cardiac function (systolic and diastolic function) in patients with coronary artery disease (CAD).

METHODS

Fifty-five patients with established CAD were selected, and serum levels of anti-ox-LDL IgG and PAB values were measured and compared with 40 matched healthy controls. Systolic and diastolic functions were determined for all patients.

RESULTS

PAB values were significantly higher in patients than in controls (p < 0.001), whilst serum anti-ox-LDL concentrations were not statistically different between the 2 groups (p = 0.821). However, after adjustment for high-density lipoprotein cholesterol, the patients had higher anti-ox-LDL levels (p = 0.04). Total PAB values were inversely associated with ejection fraction (r = -0.326, p = 0.031), but this was not the case for anti-ox-LDL in either group (p > 0.05).

CONCLUSION

Serum concentrations of a marker of oxidative stress (PAB values) are inversely associated with cardiac function. PAB is a relatively simple index that could be incorporated into risk assessment in CAD patients. Anti-ox-LDL IgG antibody concentration does not appear to reflect total oxidative stress as assessed by PAB.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Subjects: R Medicine > R Medicine (General) > R735 Medical education
Depositing User: Gordon Ferns
Date Deposited: 16 Nov 2012 14:27
Last Modified: 16 Nov 2012 14:36
URI: http://sro.sussex.ac.uk/id/eprint/42619
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