Riluzole protects against glutamate-induced slowing of neurofilament axonal transport

Stevenson, Alison, Yates, Darran M, Manser, Catherine, De Vos, Kurt J, Vagnoni, Alessio, Leigh, P Nigel, McLoughlin, Declan M and Miller, Christopher C J (2009) Riluzole protects against glutamate-induced slowing of neurofilament axonal transport. Neuroscience Letters, 454 (2). pp. 161-4. ISSN 0304-3940

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Abstract

Riluzole is the only drug approved for the treatment of amyotrophic lateral sclerosis (ALS) but its precise mode of action is not properly understood. Damage to axonal transport of neurofilaments is believed to be part of the pathogenic mechanism in ALS and this has been linked to defective glutamate handling and increased phosphorylation of neurofilament side-arm domains. Here, we show that riluzole protects against glutamate-induced slowing of neurofilament transport. Protection is associated with decreased neurofilament side-arm phosphorylation and inhibition of the activities of two neurofilament kinases, ERK and p38 that are activated in ALS. Thus, the anti-glutamatergic properties of riluzole include protection against glutamate-induced changes to neurofilament phosphorylation and transport

Item Type: Article
Keywords: Amyotrophic lateral sclerosis; Motor neuron disease; Extracellular-regulated kinase; Neurofilament; Axonal transport
Schools and Departments: Brighton and Sussex Medical School > Clinical Medicine
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
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Depositing User: Patricia Butler
Date Deposited: 15 Nov 2012 15:03
Last Modified: 15 Nov 2012 15:03
URI: http://sro.sussex.ac.uk/id/eprint/42508
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