Common variants at 11p13 are associated with susceptibility to tuberculosis

Thye, T, Owusu-Dabo, E, Vannberg, F, Crevel, R, Curtis, James, Sahiratmadja, E, Balabanova, Y, Ehmen, C, Muntau, B, Ruge, G, Sieversten, J, Gyapong, J, Nikolayevskyy, V, Hill, P, Sirugo, G, Drobniewski, F, Van de Vosse, E, Newport, Melanie, Alisjahbana, B, Nejentsev, S, Ottenhoff, T, Hill, Adrian V S, Horstmann, R and Meyer, C (2012) Common variants at 11p13 are associated with susceptibility to tuberculosis. Nature Genetics, 44 (3). pp. 257-259. ISSN 1061-4036

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Abstract

After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10−9). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10−11.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Primary Care and Public Health
Subjects: Q Science
Depositing User: Deeptima Massey
Date Deposited: 14 Nov 2012 14:58
Last Modified: 14 Nov 2012 14:58
URI: http://sro.sussex.ac.uk/id/eprint/42499
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