Deletion variant of alpha2b-adrenergic receptor gene moderates the effect of COMT val(158)met polymorphism on episodic memory performance

Gibbs, Ayana A, Naudts, Kris H, Azevedo, Ruben T and David, Anthony S (2010) Deletion variant of alpha2b-adrenergic receptor gene moderates the effect of COMT val(158)met polymorphism on episodic memory performance. European Neuropsychopharmacology, 20 (4). pp. 272-275. ISSN 0924-977X

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Abstract

The COMT val(158) variant has been associated with impaired cognitive function compared to the met(158) variant yet gene-gene interactions are not well described. In this study we demonstrate an interaction between this COMT polymorphism and a deletion variant of ADRA2B, the gene encoding the alpha2b-adrenergic receptor on episodic memory performance. Specifically, carriage of the ADRA2B deletion abolished the relative memory impairment in homozygous COMT val(158) carriers compared to met(158) carriers

Item Type: Article
Keywords: CATECHOL-O-METHYLTRANSFERASE; PREFRONTAL CORTEX; MODULATION; DOPAMINE; AMYGDALA; COGNITION; GENOTYPE; STIMULI; PROTEIN; STRESS
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Subjects: R Medicine > R Medicine (General) > R895 Medical physics. Medical radiology. Nuclear medicine
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
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Depositing User: Hazelle Woodhurst
Date Deposited: 14 Nov 2012 14:46
Last Modified: 11 Jun 2013 09:34
URI: http://sro.sussex.ac.uk/id/eprint/42455
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