Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin

Bossert, Jennifer M, Stern, Anna L, Theberge, Florence R M, Cifani, Carlo, Koya, Eisuke, Hope, Bruce T and Shaham, Yavin (2011) Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin. Nature Neuroscience, 14 (4). pp. 420-422. ISSN 1097-6256

Full text not available from this repository.

Abstract

In a rat model of context-induced relapse to heroin, we identified sparsely distributed ventral medial prefrontal cortex (mPFC) neurons that were activated by the heroin-associated context. Selective pharmacogenetic inactivation of these neurons inhibited context-induced drug relapse. A small subset of ventral mPFC neurons formed neuronal ensembles that encode the learned associations between heroin reward and heroin-associated contexts; re-activation of these neuronal ensembles by drug-associated contexts during abstinence provoked drug relapse

Item Type: Article
Schools and Departments: School of Psychology > Psychology
Subjects: B Philosophy. Psychology. Religion
Depositing User: Lene Hyltoft
Date Deposited: 14 Nov 2012 13:49
Last Modified: 11 Jun 2013 14:29
URI: http://sro.sussex.ac.uk/id/eprint/42435
📧 Request an update