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Changes in pro-oxidant-antioxidant balance after bare metal and drug eluting stent implantation in patients with stable coronary disease

journal contribution
posted on 2023-06-08, 13:33 authored by Homa Falsoleiman, Mashalla Dehghani, Mohsen Moohebati, Afsoon Fazlinezhad, Mahdi Hassanzadeh Daloee, Daryoush Hamidi Alamdari, Habib Ollah Esmaily, Seyyed Mohammad Reza Parizadeh, Shima Tavallaie, Amir Ali Rahsepar, Roghayeh Paydar, Seyyed Mohammad Reza Kazemi-Bajestani, Hossein Pourghadam-Yari, Parisa Abbasi Parizad, Majid Ghayour-Mobarhan, Gordon FernsGordon Ferns
OBJECTIVES In this study we aimed to assess the changes in pro-oxidant-antioxidant balance (PAB) after the placement of either a drug-eluting-stent (DES) or bare-metal-stent (BMS) in patients with stable coronary artery disease. DESIGN AND METHODS Percutaneous coronary interventions (PCI) with either BMS or DES were undertaken for 152 patients (82 in the BMS and 70 in the DES groups respectively). PAB values were measured 24h before and after PCI. RESULTS Baseline PAB values were 80.68 (64.98-99.37) and 98.86 (64.70-140.62) for BMS and DES group, respectively, which were not significantly different between the 2 groups (P>0.05). Following PCI, median PAB values decreased to 72.10 (61.40-96.13) and 81.40 (54.15-121.90) in BMS and DES groups, respectively. The reduction was significant in both BMS and DES groups (P<0.05). The changes in PAB values were -2.81 (-12.76 to 2.31) for BMS and -2.82 (-29.88 to 8.93) for DES group, which were not significantly different between the 2 groups (P>0.05). CONCLUSION We found that the reported difference in clinical outcomes following DES or BMS implantation cannot be attributed to differences in early changes in oxidative stress induction as assessed by changes in PAB values.

History

Publication status

  • Published

Journal

Clinical Biochemistry

ISSN

0009-9120

Publisher

Elsevier

Issue

2-3

Volume

44

Page range

160-164

Department affiliated with

  • Division of Medical Education Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-11-19

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