Selenium supplementation and premature (pre-labour) rupture of membranes: a randomised double-blind placebo-controlled trial

Tara, F, Rayman, M P, Boskabadi, H, Ghayour-Mobarhan, M, Sahebkar, A, Yazarlu, O, Ouladan, S, Tavallaie, S, Azimi-Nezhad, M, Shakeri, M T, Teymoori, M S, Razavi, B S, Oladi, M and Ferns, G (2010) Selenium supplementation and premature (pre-labour) rupture of membranes: a randomised double-blind placebo-controlled trial. Journal of obstetrics and gynaecology, 30 (1). pp. 30-34. ISSN 0144-3615

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Abstract

The aim was to determine if selenium supplementation during pregnancy reduces the occurrence of premature (pre-labour) rupture of membranes (PROM). A total of 166 primigravid pregnant women in the first trimester of pregnancy, were randomised to receive 100 mg of selenium (n = 83, drop-outs = 22) or a placebo (n = 83, drop-outs = 19) per day until delivery. The incidence of PROM, as well as serum selenium concentrations were evaluated at baseline and at the end of the study. Supplementation with selenium was associated with a significant increase in mean serum selenium concentration at term (p < 0.001). In contrast, mean serum selenium concentration remained unchanged in the control group (p > 0.05). The incidence of PROM was significantly lower in the selenium group (n = 8, 13.1%) than in the control group (n = 22, 34.4%) (p < 0.01). Our findings indicate that selenium supplementation (100 mu g/day) in pregnant women effectively reduces the incidence of PROM

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Subjects: R Medicine > RG Gynecology and obstetrics > RG0500 Obstetrics > RG0940 Maternal care. Prenatal care services
Depositing User: Gordon Ferns
Date Deposited: 12 Nov 2012 08:52
Last Modified: 12 Nov 2012 08:53
URI: http://sro.sussex.ac.uk/id/eprint/42090
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