The relationship between glycosylated haemoglobin (HbA1c) and measures of insulin resistance across a range of glucose tolerance

Borai, Anwar, Livingstone, Callum, Abdelaal, Fatima, Bawazeer, Ali, Keti, Vuyolethu and Ferns, Gordon (2011) The relationship between glycosylated haemoglobin (HbA1c) and measures of insulin resistance across a range of glucose tolerance. Scandinavian Journal of Clinical & Laboratory Investigation, 71 (2). pp. 168-172. ISSN 0036-5513

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Abstract

AIM

This study aimed to assess the correlation between HbA1c and insulin resistance as measured by a variety of different indices in subjects from across the glycaemic spectrum.

METHODS

Subjects with normal glucose tolerance (NGT; n = 24), impaired fasting glucose (IFG; n = 12), impaired glucose tolerance (IGT; n = 12), and type 2 diabetes (DM; n = 13) were studied. All had specimens taken in the context of a standard oral glucose tolerance test at their first visit and had the insulin sensitivity parameter (Si) determined by frequently-sampled intravenous glucose tolerance test at a second visit.

RESULTS

HbA1c was more strongly associated with Si in NGT (r = - 0.65) than in IFG (r = - 0.48). Compared to other indices of insulin resistance HbA1c has minimal overlap in values (0.0%) between NGT and subjects with type 2 diabetes.

CONCLUSIONS

HbA1c can be used as a simple and reliable marker of insulin resistance in NGT adults with relatively high insulin sensitivity.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Subjects: R Medicine > RB Pathology > RB037 Clinical pathology. Laboratory technique
Depositing User: Gordon Ferns
Date Deposited: 12 Nov 2012 08:37
Last Modified: 19 Nov 2012 15:02
URI: http://sro.sussex.ac.uk/id/eprint/42086
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