High frequency of Neuropeptide Y Leu7Pro polymorphism in an Iranian population and its association with coronary artery disease

Masoudi-Kazemabad, Ali, Jamialahmadi, Khadijeh, Moohebati, Mohsen, Mojarrad, Majid, Dehghan-Manshadi, Raheleh, Forghanifard, Mohammad Mahdi, Akhlaghi, Saeed, Ferns, Gordon A and Ghayour-Mobarhan, Majid (2012) High frequency of Neuropeptide Y Leu7Pro polymorphism in an Iranian population and its association with coronary artery disease. Gene, 496 (1). pp. 22-27. ISSN 0378-1119

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Abstract

Objective: Neuropeptide Y (NPY), a 36-amino acid peptide, is widely expressed in the central and peripheral nervous systems as well as in the heart. A relationship has been reported between NPY gene variants and coronary artery disease (CAD) in some populations. However, there are few data on the NPY gene polymorphism and CAD in the Persian population. In the current study we have investigated the relationship between the NPY Leu7Pro polymorphism and CAD within a population from Iran

Methods: A total of 1061 subjects were recruited; 609 patients and 452 healthy subjects. Four hundred and twenty eight of the patients had >50% stenosis; with the remaining 181 patients having <50% stenosis based on angiography. Angiography positive patients were divided into three groups: those with single (n = 115), double (n = 140), and triple vessel (n = 173) disease. DNA analysis for the Leu7Pro polymorphism was performed using a PCR-RFLP technique.

Results: A significantly higher frequency of the Leu7Pro genotype was observed in CAD patients compared with the control group (P<0.05). Patients with the Pro7 had significantly higher values for weight (P = 0.027), BMI (P = 0.001), hip circumference (P = 0.003) and prevalence of diabetes mellitus (P = 0.018) but reduced prevalence of a history of myocardial infarction (P = 0.017).

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Subjects: R Medicine > RB Pathology > RB037 Clinical pathology. Laboratory technique
Depositing User: Gordon Ferns
Date Deposited: 12 Nov 2012 08:22
Last Modified: 12 Nov 2012 08:22
URI: http://sro.sussex.ac.uk/id/eprint/42081
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