Glomerular filtration rate estimation by use of a correction formula for slope-intercept plasma iohexol clearance in cats

Finch, Natalie C, Syme, Harriet M, Elliott, Jonathan, Peters, Adrien M, Gerritsen, Robert, Croubels, Siska and Heiene, Reidun (2011) Glomerular filtration rate estimation by use of a correction formula for slope-intercept plasma iohexol clearance in cats. American Journal of Veterinary Research, 72 (12). pp. 1652-9. ISSN 1943-5681

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Abstract

OBJECTIVE

To develop a formula for correcting slope-intercept plasma iohexol clearance in cats and to compare clearance of total iohexol (TIox), endo-iohexol (EnIox), and exo-iohexol (ExIox).

ANIMALS

20 client-owned, healthy adult and geriatric cats.

PROCEDURES

Plasma clearance of TIox was determined via multisample and slope-intercept methods. A multisample method was used to determine clearance for EnIox and ExIox. A second-order polynomial correction factor was derived by performing regression analysis of the multisample data with the slope-intercept data and forcing the regression line though the origin. Clearance corrected by use of the derived formula was compared with clearance corrected by use of Brochner-Mortensen human and Heiene canine formulae. Statistical testing was applied, and Bland-Altman plots were created to assess the degree of agreement between TIox, EnIox, and ExIox clearance.

RESULTS

Mean ± SD iohexol clearance estimated via multisample and corrected slope-intercept methods was 2.16 ± 0.35 mL/min/kg and 2.14 ± 0.34 mL/min/kg, respectively. The derived feline correction formula was Cl(corrected) = (1.036 × Cl(uncorrected)) - (0.062 × Cl(uncorrected)(2)), in which Cl represents clearance. Results obtained by use of the 2 methods were in excellent agreement. Clearance corrected by use of the Heiene formula had a linear relationship with clearance corrected by use of the feline formula; however, the relationship of the feline formula with the Brochner-Mortensen formula was nonlinear. Agreement between TIox, EnIox, and ExIox clearance was excellent.

CONCLUSIONS AND CLINICAL RELEVANCE

The derived feline correction formula applied to slope-intercept plasma iohexol clearance accurately predicted multisample clearance in cats. Use of this technique offers an important advantage by reducing stress to cats associated with repeated blood sample collection and decreasing the costs of analysis

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical Medicine
Subjects: R Medicine > RC Internal medicine > RC0071 Examination. Diagnosis Including radiography
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Depositing User: Ellen Thomas
Date Deposited: 12 Nov 2012 09:07
Last Modified: 12 Nov 2012 09:07
URI: http://sro.sussex.ac.uk/id/eprint/42040
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