University of Sussex
Browse

File(s) not publicly available

Plasma fetuin-A is associated with the severity of cognitive impairment in mild-to-moderate Alzheimer's disease

journal contribution
posted on 2023-06-08, 13:27 authored by Edward R Smith, Ramin Nilforooshan, Gary Weaving, Naji Tabet
The significance of vascular risk factors in the development and progression of Alzheimer's disease (AD) is now widely recognized. Fetuin-A is an abundant plasma protein that predicts vascular risk in a variety of clinical settings. In the context of cerebral ischemia, fetuin-A appears to be anti-inflammatory. Given the apparent importance of neuroinflammation in cognitive decline, we analyzed fetuin-A concentrations and pro-inflammatory cytokine levels in a cohort of 34 patients with mild-to-moderate AD, and compared these to age-matched controls. Further, we analyzed the relationship between plasma fetuin-A concentration and a measure of cognitive impairment using multivariate regression modeling. Plasma fetuin-A concentrations were lower in the patient group (p = 0.006) compared with controls and were significantly correlated with Mini-Mental State Examination (MMSE) score (r = 0.504, p = 0.002). Fetuin-A concentration was also significantly and inversely correlated with plasma TNF-a concentration (r = -0.496, p = 0.003). The association between MMSE performance and fetuin-A was maintained even after multivariate adjustment for other risk factors including TNF-a (adjusted R² total = 0.371). Using this model, plasma fetuin-A concentration explained 21% of the variance in MMSE scores. Further studies are needed to evaluate whether fetuin-A is related to the progression and pathogenesis of AD.

History

Publication status

  • Published

Journal

Journal of Alzheimer's Disease

ISSN

1875-8908

Publisher

IOS Press

Issue

2

Volume

24

Page range

327-333

Department affiliated with

  • Division of Medical Education Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-11-02

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC