Plasma fetuin-A is associated with the severity of cognitive impairment in mild-to-moderate Alzheimer's disease

Smith, Edward R, Nilforooshan, Ramin, Weaving, Gary and Tabet, Naji (2011) Plasma fetuin-A is associated with the severity of cognitive impairment in mild-to-moderate Alzheimer's disease. Journal of Alzheimer's Disease, 24 (2). pp. 327-333. ISSN 1875-8908

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Abstract

The significance of vascular risk factors in the development and progression of Alzheimer's disease (AD) is now widely recognized. Fetuin-A is an abundant plasma protein that predicts vascular risk in a variety of clinical settings. In the context of cerebral ischemia, fetuin-A appears to be anti-inflammatory. Given the apparent importance of neuroinflammation in cognitive decline, we analyzed fetuin-A concentrations and pro-inflammatory cytokine levels in a cohort of 34 patients with mild-to-moderate AD, and compared these to age-matched controls. Further, we analyzed the relationship between plasma fetuin-A concentration and a measure of cognitive impairment using multivariate regression modeling. Plasma fetuin-A concentrations were lower in the patient group (p = 0.006) compared with controls and were significantly correlated with Mini-Mental State Examination (MMSE) score (r = 0.504, p = 0.002). Fetuin-A concentration was also significantly and inversely correlated with plasma TNF-α concentration (r = -0.496, p = 0.003). The association between MMSE performance and fetuin-A was maintained even after multivariate adjustment for other risk factors including TNF-α (adjusted R² total = 0.371). Using this model, plasma fetuin-A concentration explained 21% of the variance in MMSE scores. Further studies are needed to evaluate whether fetuin-A is related to the progression and pathogenesis of AD.

Item Type: Article
Keywords: Alpha2HS glycoprotein, Alzheimer's disease, inflammation, tumor necrosis factor-alpha
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Subjects: R Medicine
R Medicine > RC Internal medicine > RC0581 Specialties of internal medicine
R Medicine > RC Internal medicine > RC0581 Specialties of internal medicine > RC0952 Geriatrics
Depositing User: Tracey O'Gorman
Date Deposited: 02 Nov 2012 13:21
Last Modified: 02 Nov 2012 13:21
URI: http://sro.sussex.ac.uk/id/eprint/41997
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