Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity

Ebrahimi, Mahmoud, Ghayour-Mobarhan, Majid, Rezaiean, Samaneh, Hoseini, Maryam, Parizade, Seyyed Mohamad Reza, Farhoudi, Fatemeh, Hosseininezhad, Syyed Javad, Tavallaei, Shima, Vejdani, Amirhosein, Azimi-Nezhad, Mohsen, Shakeri, Mohamad Taghi, Rad, Mina Akbari, Mobarra, Naser, Kazemi-Bajestani, Seyyed Mohammad Reza and Ferns, Gordon A A (2009) Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity. Acta Cardiologica, 64 (3). pp. 321-327. ISSN 1784-973X

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Abstract

OBJECTIVE

Fish-oil contains high concentrations of omega-3 fatty acids that have been shown to have anti-inflammatory properties. We have evaluated the effects of purified omega-3 fatty acid supplements on several anthropometric and biochemical parameters, including heat shock protein (Hsp) 27 antibody titres in subjects with metabolic syndrome.

METHODS

Subjects (n = 120) with metabolic syndrome (mean age of 52.9 +/- 11.9 years) were randomly allocated to one of two groups: sixty subjects were given 1 gram of fish oil as a single capsule, containing 180 mg eicosapentaenoic acid and 120 mg docosahexaenoic acid daily for 6 months. Control subjects did not receive any supplementation over the same period.

RESULTS

The study was completed by 47 subjects in the intervention group and 42 subjects in the control group. Treatment with omega 3 supplements was associated with a significant fall in body weight (P < 0.05), systolic blood pressures (P < 0.05), serum low density lipoprotein cholesterol (P < 0.05), and total cholesterol (P < 0.05), triglycerides (P < 0.05), high-sensitivity C-reactive protein (hs-CRP) (P < 0.01), and Hsp27 antibody titres (P < 0.05). No significant changes were observed in the control group.

CONCLUSION

It appears that omega 3 improves the cardiovascular risk profile of subjects with metabolic syndrome, having effects on weight, systolic blood pressure, lipid profile and markers of inflammation and autoimmunity.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical Medicine
Subjects: R Medicine
Depositing User: Ellen Thomas
Date Deposited: 02 Nov 2012 13:51
Last Modified: 02 Nov 2012 13:51
URI: http://sro.sussex.ac.uk/id/eprint/41945
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