Association between indices of body mass and antibody titers to heat-shock protein-27 in healthy subjects

Tavallaie, Shima, Rahsepar, Amir Ali, Abdi, Hamid, Moohebati, Mohsen, Moodi, Fatemeh, Pourghadamyari, Hossein, Esmaily, Habibollah, Khorashadizadeh, Fatemeh, Ghayour-Mobarhan, Majid and Ferns, Gordon A A (2012) Association between indices of body mass and antibody titers to heat-shock protein-27 in healthy subjects. Clinical biochemistry, 45 (1-2). pp. 144-147. ISSN 1873-2933

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Abstract

OBJECTIVES

We have assessed the relationship between indices of adiposity and antibody titers to Hsp-27 in healthy subjects.

DESIGN

Two-hundred and fifty subjects were studied, including 50 normal-weight subjects (body-mass-index (BMI) 25 kg/m(2)), 100 overweight subjects (BMI 25 to 30 kg/m(2)) (n=100) and 100 obese subjects (BMI ≥ 30 kg/m(2)).

RESULTS

Anti-Hsp27-antibody levels in obese subjects were [0.34 (0.20-0.39) absorbency unit], being significantly higher than overweight and normal-weight groups (P<0.05). Anti-Hsp27-antibody levels in overweight subjects [0.29 (0.15-0.34) absorbency unit] were statistically higher than controls [0.18 (0.10-0.23) absorbency unit] (P<0.05).

CONCLUSION

High anti-Hsp-27-antibody levels in obese-subjects without established coronary disease may be related to a heightened state of immunoactivation associated with obesity.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical Medicine
Subjects: R Medicine
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Depositing User: Ellen Thomas
Date Deposited: 12 Nov 2012 10:15
Last Modified: 12 Nov 2012 10:15
URI: http://sro.sussex.ac.uk/id/eprint/41941
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