File(s) not publicly available
Association between indices of body mass and antibody titers to heat-shock protein-27 in healthy subjects
journal contribution
posted on 2023-06-08, 13:25 authored by Shima Tavallaie, Amir Ali Rahsepar, Hamid Abdi, Mohsen Moohebati, Fatemeh Moodi, Hossein Pourghadamyari, Habibollah Esmaily, Fatemeh Khorashadizadeh, Majid Ghayour-Mobarhan, Gordon FernsGordon FernsOBJECTIVES We have assessed the relationship between indices of adiposity and antibody titers to Hsp-27 in healthy subjects. DESIGN Two-hundred and fifty subjects were studied, including 50 normal-weight subjects (body-mass-index (BMI) 25 kg/m(2)), 100 overweight subjects (BMI 25 to 30 kg/m(2)) (n=100) and 100 obese subjects (BMI = 30 kg/m(2)). RESULTS Anti-Hsp27-antibody levels in obese subjects were [0.34 (0.20-0.39) absorbency unit], being significantly higher than overweight and normal-weight groups (P<0.05). Anti-Hsp27-antibody levels in overweight subjects [0.29 (0.15-0.34) absorbency unit] were statistically higher than controls [0.18 (0.10-0.23) absorbency unit] (P<0.05). CONCLUSION High anti-Hsp-27-antibody levels in obese-subjects without established coronary disease may be related to a heightened state of immunoactivation associated with obesity.
History
Publication status
- Published
Journal
Clinical BiochemistryISSN
0009-9120Publisher
ElsevierIssue
1-2Volume
45Page range
144-147Department affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-11-12Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC