Voxel-wise analysis of diffusion tensor MRI improves the confidence of diagnosis of corticobasal degeneration non-invasively

Bozzali, M, Cercignani, M, Baglio, F, Scotti, G, Farina, E, Pugnetti, L, Ashburner, J, Nemni, R and Falini, A (2008) Voxel-wise analysis of diffusion tensor MRI improves the confidence of diagnosis of corticobasal degeneration non-invasively. Parkinsonism and Related Disorders, 14 (5). pp. 436-439. ISSN 1353-8020

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Abstract

Corticobasal degeneration (CBD) presents with symptoms that often overlap with other neurological conditions. In many cases, diagnosis, prognosis and consequent clinical management remain uncertain. Structural and functional asymmetric brain changes represent the most consistent imaging findings that may assist in CBD diagnosis. Diffusion Tensor MRI (DT-MRI) is a quantitative technique that allows microscopic tissue abnormalities to be non-invasively assessed in vivo. A single case of clinically suspected CBD with symmetric diffuse brain atrophy on conventional-MRI scans was studied using DT-MRI by voxel-wise comparison with eight healthy subjects. The lateralized distribution of DT-MRI abnormalities was consistent with clinical features providing a substantial support to the diagnosis.

Item Type: Article
Keywords: Diffusion tensor imaging; Corticobasal degeneration; MRI; EEG; SPECT
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > R Medicine (General) > R895 Medical physics. Medical radiology. Nuclear medicine
Depositing User: Patricia Butler
Date Deposited: 29 Oct 2012 12:13
Last Modified: 03 Aug 2017 18:06
URI: http://sro.sussex.ac.uk/id/eprint/41617
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