Predicting progression in primary progressive multiple sclerosis: a 10-year multicenter study

Khaleeli, Zhaleh, Ciccarelli, Olga, Manfredonia, Francesco, Barkhof, Frederik, Brochet, Bruno, Cercignani, Mara, Dousset, Vincent, Filippi, Massimo, Montalban, Xavier, Polman, Chris, Rovaris, Marco, Rovira, Alex, Sastre-Garriga, Jaume, Vellinga, Machteld, Miller, David and Thompson, Alan (2008) Predicting progression in primary progressive multiple sclerosis: a 10-year multicenter study. Annals of Neurology, 63 (6). pp. 790-793. ISSN 1531-8249

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Abstract

Rates of progression vary widely in primary progressive multiple sclerosis. This multicenter study aimed to identify predictors of progression over 10 years. A total of 101 patients who had been imaged at baseline and 2 years were scored on the expanded disability status scale after 10 years. Ordinal logistic regression identified the following independent variables that predicted progression: male sex, shorter disease duration, and slower timed walk test at baseline (best overall predictor), and deterioration in expanded disability status scale score and reduction in brain volume over 2 years. These predictors of long-term disability provide some insight into disease progression.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Laboratory Investigation
Subjects: R Medicine > R Medicine (General) > R895 Medical physics. Medical radiology. Nuclear medicine
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
Depositing User: Patricia Butler
Date Deposited: 01 Nov 2012 15:21
Last Modified: 01 Nov 2012 15:21
URI: http://sro.sussex.ac.uk/id/eprint/41616
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