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A highly sensitive radial diffusion measurement method for white matter tract investigation

journal contribution
posted on 2023-06-08, 12:51 authored by Fabrizio Fasano, Marco Bozzali, Mara Cercignani, Gisela E Hagberg
This article describes a novel approach for local estimation of the radial diffusion coefficient (D(perpendicular)) in white matter (WM) regions containing well-oriented nervous fibers. The method is based on the assumption that the diffusion process in well-organized WM regions responds to a cylindrical symmetry. The increased precision in the estimation of D(perpendicular) provided by this local approach compared to standard techniques based on diffusion tensor imaging is demonstrated using numerical simulations. An in vivo validation of the technique is also provided, showing its application to the corpus callosum of six healthy volunteers, highlighting the sensitivity of the method. Assuming that D(perpendicular) is sensitive to myelin integrity, our technique has the potential to investigate pathophysiological aspects of several neurological and psychiatric disorders with improved precision in targeted WM tracts.

History

Publication status

  • Published

Journal

Magnetic Resonance Imaging

ISSN

1873-5894

Publisher

Elsevier

Issue

4

Volume

27

Page range

519-530

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-10-29

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