File(s) not publicly available
A highly sensitive radial diffusion measurement method for white matter tract investigation
journal contribution
posted on 2023-06-08, 12:51 authored by Fabrizio Fasano, Marco Bozzali, Mara Cercignani, Gisela E HagbergThis article describes a novel approach for local estimation of the radial diffusion coefficient (D(perpendicular)) in white matter (WM) regions containing well-oriented nervous fibers. The method is based on the assumption that the diffusion process in well-organized WM regions responds to a cylindrical symmetry. The increased precision in the estimation of D(perpendicular) provided by this local approach compared to standard techniques based on diffusion tensor imaging is demonstrated using numerical simulations. An in vivo validation of the technique is also provided, showing its application to the corpus callosum of six healthy volunteers, highlighting the sensitivity of the method. Assuming that D(perpendicular) is sensitive to myelin integrity, our technique has the potential to investigate pathophysiological aspects of several neurological and psychiatric disorders with improved precision in targeted WM tracts.
History
Publication status
- Published
Journal
Magnetic Resonance ImagingISSN
1873-5894Publisher
ElsevierExternal DOI
Issue
4Volume
27Page range
519-530Department affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-10-29Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC