Magnetization transfer ratio in gray matter: a potential surrogate marker for progression in early primary progressive multiple sclerosis

Khaleeli, Zhaleh, Altmann, Daniel R, Cercignani, Mara, Ciccarelli, Olga, Miller, David H and Thompson, Alan J (2008) Magnetization transfer ratio in gray matter: a potential surrogate marker for progression in early primary progressive multiple sclerosis. Archives of Neurology, 65 (11). pp. 1454-1459. ISSN 1531-8249

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Abstract

BACKGROUND

Magnetization transfer imaging has the potential to provide a surrogate marker for progression in primary progressive multiple sclerosis (PPMS).

OBJECTIVES

To investigate whether brain magnetization transfer imaging, T2 lesion load, and atrophy changes over 3 years reflect concurrent clinical changes, and which baseline imaging measure best predicts progression over 3 years in early PPMS.

DESIGN

Prospective study.

SETTING

National Hospital for Neurology and Neurosurgery and the Institute of Neurology, London, England.

PATIENTS

Forty-seven patients with PPMS (of whom 43 completed the study) and 18 control subjects.

INTERVENTIONS

Brain magnetization transfer imaging (including T2-weighted images) and volume sequences every 6 months for 3 years.

MAIN OUTCOME MEASURES

Changes in Expanded Disability Status Scale (EDSS) score and associations with rate of change in imaging variables.

RESULTS

More rapid decline in gray matter mean and peak location magnetization transfer ratio and T2 lesion load increase were associated with greater rates of progression on the EDSS. Baseline gray matter peak height magnetization transfer ratio best predicted progression over 3 years.

CONCLUSION

Gray matter magnetization transfer ratio meets many of the criteria for a surrogate marker of progression in early PPMS.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Laboratory Investigation
Subjects: R Medicine > R Medicine (General) > R895 Medical physics. Medical radiology. Nuclear medicine
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
Depositing User: Patricia Butler
Date Deposited: 01 Nov 2012 15:28
Last Modified: 01 Nov 2012 15:28
URI: http://sro.sussex.ac.uk/id/eprint/41613
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