No evidence for a large difference in ALS frequency in populations of African and European origin: a population based study in inner city London

Rojas-Garcia, Ricardo, Scott, Kirsten M, Roche, Jose Carlos, Scotton, William, Martin, Naomi, Janssen, Anna, Goldstein, Laura H, Leigh, Nigel, Ellis, Cathy M, Shaw, Christopher E and Al-Chalabi, Ammar (2012) No evidence for a large difference in ALS frequency in populations of African and European origin: a population based study in inner city London. Amyotrophic Lateral Sclerosis, 13 (1). pp. 66-68. ISSN 1471-180X

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Abstract

Abstract Previous studies have suggested a lower incidence of ALS in people of African origin. We used a population based register in an urban setting from inner city London postcodes where there is a large population of people of African ancestry to compare the frequency of ALS in people of European and African origin. Population statistics stratified by age, gender and ethnicity were obtained from the 2001 census. Incidence and prevalence were calculated in each ethnic group. Results showed that in a population of 683,194, of which 22% were of African ancestry, 88 individuals with ALS were identified over a seven-year period, including 14 people with African ancestry. The adjusted incidence in people of African ancestry was 1.35 per 100,000 person-years (95% CI 0.72-2.3) and in those of European ancestry 1.97 per 100,000 person-years (95% CI 1.55-2.48). In conclusion, in this small population based study we could not detect a difference in rates of ALS between people of African ancestry and those of European ancestry.

Item Type: Article
Keywords: Population based register, amyotrophic lateral sclerosis, ethnicity, incidence
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
Depositing User: Patricia Butler
Date Deposited: 09 Nov 2012 15:47
Last Modified: 25 Sep 2017 13:39
URI: http://sro.sussex.ac.uk/id/eprint/41504
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