Tuberculin-specific T cells are reduced in active pulmonary tuberculosis compared to LTBI or status post BCG vaccination

Streitz, M, Fuhrmann, S, Powell, F, Quassem, A, Nomura, L, Maecker, H, Martus, P, Volk, H D and Kern, F (2011) Tuberculin-specific T cells are reduced in active pulmonary tuberculosis compared to LTBI or status post BCG vaccination. Journal of Infectious Diseases, 203 (3). pp. 378-382. ISSN 0022-1899

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Abstract

Functional characteristics of tuberculosis (TB)-specific CD4 T cells were studied in clinically active pulmonary TB (n = 21) and high TB exposure including LTBI (n = 17). Following tuberculin stimulation, activated CD4 T cells were identified by flow-cytometry (CD154 up-regulation, degranulation, interferon gamma [IFN-gamma], tumor necrosis factor alpha [TNF-alpha], and interleukin 2 [IL-2\ production). Interestingly, CD154 up-regulation accounted for approximately 80% of activated CD4 T cells in the active TB group but just 40% in the controls, whereas IFN-gamma accounted for only approximately 50% of activated cells in each group. The frequencies of CD4 T cells displaying at least 1 activation marker discriminated better between the groups than those displaying degranulation or IFN-gamma production alone.

Item Type: Article
Keywords: Adult BCG Vaccine/*immunology CD40 Ligand/genetics/metabolism Female Gene Expression Regulation Humans Male Middle Aged T-Lymphocytes/immunology/*physiology Tuberculin/*immunology Tuberculosis, Pulmonary/blood/*immunology/pathology/prevention & control Tumor Necrosis Factor-alpha/genetics/metabolism
Schools and Departments: Brighton and Sussex Medical School > Clinical Medicine
Subjects: Q Science > QR Microbiology > QR0180 Immunology
Depositing User: Florian Kern
Date Deposited: 23 Oct 2012 15:08
Last Modified: 23 Oct 2012 15:08
URI: http://sro.sussex.ac.uk/id/eprint/41293
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