Secondary heterologous dengue infection risk: Disequilibrium between immune regulation and inflammation?

Sierra, B, Perez, A B, Vogt, K, Garcia, G, Schmolke, K, Aguirre, E, Alvarez, M, Kern, F, Kouri, G, Volk, H D and Guzman, M G (2010) Secondary heterologous dengue infection risk: Disequilibrium between immune regulation and inflammation? Cellular Immunology, 262 (2). pp. 134-140. ISSN 0008-8749

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Abstract

Increased serum levels of cytokines released by cells of the immune response have been detected in patients suffering from dengue disease. Likewise, secondary infections by a different dengue virus serotype result in a highest risk of development of the severe dengue disease. Both findings suggest that the memory immune response is one of the key players in the pathogenesis of this disease. Here we take advantage of the particular Cuban epidemiological situation in dengue to analyze a broad spectrum of cell-mediated immune response mediators at mRNA and protein level. Evidences for a regulatory immune pattern in homologous (TGF-beta, IL-10) vs. pro-inflammatory pattern (IFN-gamma, TNF-alpha) in heterologous dengue virus re-challenge were found, suggesting a possible association with the higher incidence of severe dengue cases in the latter case.

Item Type: Article
Keywords: Adult Cuba/epidemiology Cytokines/blood/immunology Dengue/blood/epidemiology/*immunology Dengue Virus/immunology Female Humans Immune System/immunology Immunologic Memory/*immunology Inflammation/blood/*immunology Male Middle Aged Risk Factors Young Adult
Schools and Departments: Brighton and Sussex Medical School > Clinical Medicine
Subjects: Q Science > QR Microbiology > QR0180 Immunology
Depositing User: Florian Kern
Date Deposited: 25 Oct 2012 13:10
Last Modified: 25 Oct 2012 13:10
URI: http://sro.sussex.ac.uk/id/eprint/41291
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