Learning about time: plastic changes and interindividual brain differences

Bueti, Domenica, Lasaponara, Stefano, Cercignani, Mara and Macaluso, Emiliano (2012) Learning about time: plastic changes and interindividual brain differences. Neuron, 75 (4). pp. 725-737. ISSN 1097-4199

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Learning the timing of rapidly changing sensory events is crucial to construct a reliable representation of the environment and to efficiently control behavior. The neurophysiological mechanisms underlying the learning of time are unknown. We used functional and structural magnetic resonance imaging to investigate neurophysiological changes and individual brain differences underlying the learning of time in the millisecond range. We found that the representation of a trained visual temporal interval was associated with functional and structural changes in a sensory-motor network including occipital, parietal, and insular cortices, plus the cerebellum. We show that both types of neurophysiological changes correlated with changes of performance accuracy and that activity and gray-matter volume of sensorimotor cortices predicted individual learning abilities. These findings represent neurophysiological evidence of functional and structural plasticity associated with the learning of time in humans and highlight the role of sensory-motor circuits in the perceptual representation of time in the millisecond range.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Laboratory Investigation
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
Depositing User: Mara Cercignani
Date Deposited: 18 Oct 2012 09:24
Last Modified: 09 Jul 2013 13:50
URI: http://sro.sussex.ac.uk/id/eprint/41263
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