Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?

Feldmann, M, Andreakos, E, Smith, C, Bondeson, J, Yoshimura, S, Kiriakidis, S, Monaco, C, Gasparini, C, Sacre, Sandra, Lundberg, A, Paleolog, E, Horwood, N J, Brennan, F M and Foxwell, B M J (2002) Is NF-kappaB a useful therapeutic target in rheumatoid arthritis? Annals of the Rheumatic Diseases (ARD), 61 Sup. ii13-ii18. ISSN 0003-4967

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Abstract

There is increasing evidence that NF-kappaB is a major, if not the major transcription factor regulating inflammation and immunity. While this implies that blocking NF-kappaB might be therapeutically beneficial, it raises clear questions regarding the balance between efficacy and safety. In this brief review we discuss the effects of NF-kappaB blockade in rheumatoid arthritis, inflammation and immunity, and consider possible therapeutic targets within the NF-kappaB family.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Subjects: Q Science
R Medicine
Depositing User: Sandra Sacre
Date Deposited: 01 Nov 2012 14:22
Last Modified: 05 Oct 2017 18:27
URI: http://sro.sussex.ac.uk/id/eprint/41165
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