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Molecular therapeutic targets in rheumatoid arthritis

journal contribution
posted on 2023-06-08, 12:38 authored by Sandra SacreSandra Sacre, Evangelos Andreakos, Peter TaylorPeter Taylor, Marc Feldmann, Brian M Foxwell
In an attempt to combat the pain and damage generated by rheumatoid arthritis (ra), new drugs are being developed to target molecular aspects of the disease process. Recently, a major development has been the use of biologicals (antibodies and soluble receptors) that neutralise the activity of tumour necrosis factor alpha (TNF-alpha) and interleukin 1 (IL-1), both of which are involved in disease progression. An increase in our understanding of cell and molecular biology has resulted in the identification and investigation of potential new targets, and also the refinement and improvement of current therapeutic modalities. This review describes therapies that are approved, in clinical trials or under pre-clinical investigation at the laboratory level, particularly focusing on cytokines, although other therapeutic targets of interest are mentioned.

History

Publication status

  • Published

Journal

Expert Reviews in Molecular Medicine

ISSN

1462-3994

Publisher

Cambridge University Press

Issue

16

Volume

7

Page range

1-20

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-11-01

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