The roles of miRNAs in wing imaginal disc development in Drosophila

Waldron, J A and Newbury, Sarah (2012) The roles of miRNAs in wing imaginal disc development in Drosophila. Biochemical Society Transactions, 40 (4). pp. 891-895. ISSN 0300-5127

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During development, it is essential for gene expression to occur in a very precise spatial and temporal manner. There are many levels at which regulation of gene expression can occur, and recent evidence demonstrates the importance of mRNA stability in governing the amount of mRNA that can be translated into functional protein. One of the most important discoveries in this field has been miRNAs (microRNAs) and their function in targeting specific mRNAs for repression. The wing imaginal discs of Drosophila are an excellent model system to study the roles of miRNAs during development and illustrate their importance in gene regulation. This review aims at discussing the developmental processes where control of gene expression by miRNAs is required, together with the known mechanisms of this regulation. These developmental processes include Hox gene regulation, developmental timing, growth control, specification of SOPs (sensory organ precursors) and the regulation of signalling pathways.

Item Type: Article
Keywords: Drosophila, microRNA (miRNA), sensory organ precursor, signalling pathway, Ultrabithorax, wing imaginal disc development.
Schools and Departments: Brighton and Sussex Medical School > Clinical and Laboratory Investigation
Subjects: R Medicine
Depositing User: Jil Fairclough
Date Deposited: 30 Oct 2012 15:19
Last Modified: 30 Oct 2012 15:19
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