The CHI3L1 rs4950928 polymorphism is associated with asthma-related hospital admissions in children and young adults

Cunningham, Jason, Basu, Kaninika, Tavendale, Roger, Palmer, Colin N A, Smith, Helen and Mukhopadhyay, Somnath (2011) The CHI3L1 rs4950928 polymorphism is associated with asthma-related hospital admissions in children and young adults. Annals of Allergy, Asthma and Immunology, 106 (5). pp. 381-386. ISSN 1081-1206

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Abstract

Background: Asthma exacerbations are the commonest cause of medical admissions in childhood. These have a significant effect on quality of life and are a major financial burden on worldwide healthcare services. A range of gene–environment interactions may influence the course and severity of asthma in children and their response to medication. The Chitinase 3-like 1 (CHI3L1)-131C>G genotype (rs4950928) is associated with increased asthma susceptibility and severity in adults

Objectives: To study the interactions of the Chitinase 3-Like-1 functional promoter SNP rs4950928 and its role on asthma exacerbations in a population of children and young adults with asthma.

Methods: A cross-sectional survey was undertaken using medical records and direct interviews of 1,071 children and young adults with asthma, aged 3 to 22 years, from Scotland. Saliva samples were collected for genotyping. Binary logistic regression was used to calculate odds ratios (ORs) and P-values for measures of asthma exacerbations.

Results: The minor -131G allele confers protection against asthma-related hospital admissions (OR = 0.62; 95% CI 0.41–0.92; P = .018) in children and young adults with asthma.

Conclusions: Our study shows that rs4950928 is significantly associated with hospital admissions in children and young adults; screening for rs4950928 may predict asthma-related hospital admissions, and through individually defined treatment management plans, potentially reduce health care costs.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Primary Care and Public Health
Brighton and Sussex Medical School > Clinical and Experimental Medicine
Subjects: R Medicine
Depositing User: Jessica Stockdale
Date Deposited: 09 Aug 2012 08:11
Last Modified: 29 Sep 2017 09:53
URI: http://sro.sussex.ac.uk/id/eprint/40345
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