Inter-locus antagonistic coevolution as an engine of speciation: assessment with hemiclonal analysis

Rice, William R, Linder, Jodell E, Friberg, Urban, Lew, Timothy A, Morrow, Edward H and Stewart, Andrew D (2005) Inter-locus antagonistic coevolution as an engine of speciation: assessment with hemiclonal analysis. Proceedings of the National Academy of Sciences, 102 (Sup 1). pp. 6527-6534. ISSN 0027-8424

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Abstract

One of Ernst Mayr’s legacies is the consensus that the allopatry
model is the predominant mode of speciation in most sexually
reproducing lineages. In this model, reproductive isolation develops
as a pleiotropic byproduct of the genetic divergence that
develops among physically isolated populations. Presently, there is
no consensus concerning which, if any, evolutionary process is
primarily responsible for driving the specific genetic divergence
that leads to reproductive isolation. Here, we focus on the hypothesis
that inter-locus antagonistic coevolution drives rapid genetic
divergence among allopatric populations and thereby acts as an
important ‘‘engine’’ of speciation. We assert that only data from
studies of experimental evolution, rather than descriptive patterns
of molecular evolution, can provide definitive evidence for this
hypothesis. We describe and use an experimental approach, called
hemiclonal analysis, that can be used in the Drosophila melanogaster
laboratory model system to simultaneously screen nearly
the entire genome for both standing genetic variation within a
population and the net-selection gradient acting on the variation.
Hemiclonal analysis has four stages: (i) creation of a laboratory
‘‘island population’’; (ii) cytogenetic cloning of nearly genomewide
haplotypes to construct hemiclones; (iii) measurement of
additive genetic variation among hemiclones; and (iv) measurement
of the selection gradient acting on phenotypic variation
among hemiclones. We apply hemiclonal analysis to test the
hypothesis that there is ongoing antagonistic coevolution between
the sexes in the D. melanogaster laboratory model system
and then discuss the relevance of this analysis to natural systems

Item Type: Article
Schools and Departments: School of Life Sciences > Evolution, Behaviour and Environment
Subjects: Q Science > QH Natural history > QH0301 Biology > QH0359 Evolution
Depositing User: Ted Morrow
Date Deposited: 12 Nov 2012 13:19
Last Modified: 12 Nov 2012 13:19
URI: http://sro.sussex.ac.uk/id/eprint/40264
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