From the cell membrane to the nucleus: unearthing transport mechanisms for Dynein

Crossley, Laurie, Garrett, Caroline A, Hafezparast, Majid and Madzvamuse, Anotida (2012) From the cell membrane to the nucleus: unearthing transport mechanisms for Dynein. Bulletin of Mathematical Biology, 74 (9). pp. 2032-2061. ISSN 1522-9602

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Abstract

Mutations in the motor protein cytoplasmic dynein have been found to cause Charcot-Marie-Tooth disease, spinal muscular atrophy, and severe intellectual disabilities in humans. In mouse models, neurodegeneration is observed. We sought to develop a novel model which could incorporate the effects of mutations on distance travelled and velocity. A mechanical model for the dynein mediated transport of endosomes is derived from first principles and solved numerically. The effects of variations in model parameter values are analysed to find those that have a significant impact on velocity and distance travelled. The model successfully describes the processivity of dynein and matches qualitatively the velocity profiles observed in experiments.

Item Type: Article
Keywords: Dynein; Endocytosis; Motor proteins; Transport model
Schools and Departments: School of Life Sciences > Neuroscience
Subjects: Q Science > Q Science (General)
Depositing User: Majid Hafezparast
Date Deposited: 07 Aug 2012 08:54
Last Modified: 07 Mar 2017 04:40
URI: http://sro.sussex.ac.uk/id/eprint/40241

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