Chapter 10: Regulators of G Protein Signaling in Neuropsychiatric Disorders

Terzi, Dimitra, Stergiou, Eugenia, King, Sarah L and Zachariou, Venetia (2009) Chapter 10: Regulators of G Protein Signaling in Neuropsychiatric Disorders. In: Fisher, Rory A (ed.) Molecular Biology of RGS Proteins. Progress in Molecular Biology and Translational Science, 86 . Elsevier Science, London, pp. 299-333. ISBN 9780123747594

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Abstract

Regulators of G protein signaling (RGS) comprise a diverse group of about 40 proteins which determine signaling amplitude and duration via modulation of receptor/G protein or receptor/effector coupling. Several members of the RGS family are expressed in the brain, where they have precise roles in regulation of important physiological processes. The unique functions of each RGS can be attributed to its structure, distinct pattern of expression, and regulation, and its preferential interactions with receptors, Gα subunits and other signaling proteins. Evidence suggests dysfunction of RGS proteins is related to several neuropathological conditions. Moreover, clinical and preclinical work reveals that the efficacy and/or side effects of treatments are highly influenced by RGS activity. This article summarizes findings on RGS proteins in vulnerability to several neuropsychiatric disorders, the mechanism via which RGS proteins control neuronal responses and their potential use as drug targets.

Item Type: Book Section
Schools and Departments: School of Psychology > Psychology
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
Depositing User: Library Cataloguing
Date Deposited: 28 May 2012 08:33
Last Modified: 30 Nov 2012 17:13
URI: http://sro.sussex.ac.uk/id/eprint/39441
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