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‘TamiGold’: phospha-oseltamivir-stabilised gold nanoparticles as the basis for influenza therapeutics and diagnostics targeting the neuraminidase (instead of the hemagglutinin)
journal contribution
posted on 2023-06-08, 11:36 authored by Mathew Stanley, Nicholas Cattle, John McCauley, Stephen R Martin, Abdul Rashid, Robert A Field, Benoit Carbain, Hansjoerg StreicherThe strong and selective binding of 2 types of gold nanoparticles that are decorated with the oseltamivir (aka Tamiflu) pharmacophore{,} to wild-type and resistant influenza virus strains{,} including isolates from the 2009 pandemic{,} is reported. The particles interact with the virus neuraminidase rather than the hemagglutinin and could serve as vantage point for novel influenza virus sensors{,} due to the intrinsic advantages of oseltamivir over the natural sialic acid ligand or even zanamivir.
History
Publication status
- Published
Journal
MedChemCommISSN
2040-2503Publisher
Royal Society of ChemistryExternal DOI
Issue
11Volume
3Page range
1373-1376Department affiliated with
- Biochemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-07-19Usage metrics
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