‘TamiGold’: phospha-oseltamivir-stabilised gold nanoparticles as the basis for influenza therapeutics and diagnostics targeting the neuraminidase (instead of the hemagglutinin)

Stanley, Mathew, Cattle, Nicholas, McCauley, John, Martin, Stephen R, Rashid, Abdul, Field, Robert A, Carbain, Benoit and Streicher, Hansjoerg (2012) ‘TamiGold’: phospha-oseltamivir-stabilised gold nanoparticles as the basis for influenza therapeutics and diagnostics targeting the neuraminidase (instead of the hemagglutinin). MedChemComm. ISSN 2040-2503

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Abstract

The strong and selective binding of 2 types of gold nanoparticles that are decorated with the oseltamivir (aka Tamiflu) pharmacophore{,} to wild-type and resistant influenza virus strains{,} including isolates from the 2009 pandemic{,} is reported. The particles interact with the virus neuraminidase rather than the hemagglutinin and could serve as vantage point for novel influenza virus sensors{,} due to the intrinsic advantages of oseltamivir over the natural sialic acid ligand or even zanamivir.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
Subjects: Q Science > QD Chemistry > QD0241 Organic chemistry
Depositing User: Hans Streicher
Date Deposited: 19 Jul 2012 09:57
Last Modified: 19 Jul 2012 09:57
URI: http://sro.sussex.ac.uk/id/eprint/39276
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