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Investigation of aberrant translational control of c-myc in cell lines derived from patients with multiple myeloma.
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posted on 2023-06-08, 11:24 authored by A E Willis, F E Paulin, Michelle WestMichelle West, R L WhitneyIn cell lines derived from patients with multiple myeloma (MM) we have found an elevation in the amount of the c-myc protein which is not accompanied by an increase in the level of mRNA or a change in the half-life of the protein. There is a 3.4 fold enhancement in the degree of association of the c-myc message with polysomes. This is not accompanied by an alteration in polysome size or a change in the transit time of the c-myc mRNA on the polysomes thus suggesting that there is in increase in the degree of mobilisation of the c-myc message. Sequencing of the c-myc 5'UTR has revealed the presence of a mutation in all the MM cell lines studied and we demonstrate that this mutation causes altered binding of cellular proteins to this RNA species.
History
Publication status
- Published
Journal
Current Topics in Microbiology and ImmunologyISSN
0070-217XPublisher
Springer VerlagPublisher URL
Volume
224Page range
269-276Department affiliated with
- Biochemistry Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-05-03Usage metrics
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